Endocrine Abstracts

Introduction: Primary hyperparathyroidism (PHPT) is emerging as a cause of secondary hypertension. Between 20 and 50% of patients with PHPT have hypertension, this being directly proportional to the calcemia. The elevation of blood pressure in PHPT is mediated by hypercalcemia that acts directly stimulating the contraction of muscle fibers of the arterial vessel wall, and increases plasma renin levels and the release of catecholamines.Objectives: (1) Det...

Introduction: Gender identity disorder (GID) is a disagreement between biological sexual differentiation and self-declared gender identity. The aetiology of GID remains unclear, although endocrinological, neuroanatomical and psychosocial factors are all thought to be causally involved. Polycystic ovary syndrome (PCOS) is characterized by chronic anovulation, polycystic ovarian morphology, and biochemical and/or biological signs of hyperandrogenism. Most women with PCOS also ex...

Vascular disrupting agents (VDAs) differ from angiogenesis inhibitors by attacking established tumor blood vessels rather than preventing growth of new ones. We investigated effects of the tumor-VDA ASA404 against neuroendocrine tumors of the gastroenteropancreatic system (GEP-NETs) and adrenocortical carcinoma (ACC) 24 h after treatment of BON and NCIh295 tumor bearing mice with ASA404 (A), paclitaxel (P) or the combined administration (A+P). A significant decrease in cell pr...

Objective: Vitamin D deficiency is common in polish population and seem to play role in pathogenesis of some diseases. We looked for correlation between polymorphisms BsmI, TaqI, ApaI and FokI of vitamin D receptor and vitamin D influence on goiter development.Methods: One hundred and fifty two women-96 with and 56 without nontoxic goiter were examined in 2014. In US examination we calculated the volume of the thyroid gland and volume of nodules. Blood s...

Objective: There are many suggestions of predispositions to goiter in women with benign and malignant masthopaty, we looked for BRCA1 mutations in women wit and without goiterMethods: One hundred and fifty two women-96 with and 56 without nontoxic goiter were examined in 2014. In US examination we calculated the volume of the thyroid gland and volume of nodules. Blood samples for BRCA1 were taken, ex05 - p.Cys61Gly; ex 11 polymorphisms K1183R, mutations:...

IntroductionA biosimilar is a biological medicinal product that shows high similarity to another already approved medicine product containing biotechnology-derived protein as active substance. The similarity depends on the biosimilar development program that includes comparative studies of physical and chemical properties, in vitro pharmacodynamics, pharmacokinetics and pharmacodynamics in humans. Insulin aspart biphasic 30 is one of the most co...

IntroductionNowadays thrombopoietin receptor agonists (TPO-RAs) represent a promising approach for the patients with immune thrombocytopenia (ITP). Usage of two licensed TPO-RAs, romiplostim and eltrombopag, provide efficient support of ITP patients´ platelet count and, as a consequence, better control of disease. Both agents have an acceptable toxicity profile, but there are several another disadvantages in terms of usage of these drugs such as cos...

IntroductionThe practice of screening for many chronic diseases, particularly endocrine pathology, is taking place all over the world. The relevance of screening increases significantly when we are talking about diseases with a torpid manifestation and absence of certain clinical symptoms in the debut. Such diseases include pathological conditions caused by pituitary hormone hypersecretion, in particular, acromegaly.The aim<p c...

IntroductionVitamin D (VitD) is thought to be essential for adequate testosterone (T) secretion in men. In the absence of D-hypovitaminosis, their blood T levels and T to estradiol (E2) ratio values are higher relative to those with VitD deficiency. The correlation between VitD levels and androgenization indices in men of different ages has not been practically studied.The aimTo study blood levels of T and th...

Background: Pituitary apoplexy (PA) is a rare, potentially life-threatening endocrine emergency, due to abrupt pituitary haemorrhage and/or infarction, usually within a pituitary adenoma. PA most commonly presents with severe headache, visual and oculomotor activity disturbances, nausea/vomiting and/or altered mental status. The outcome is variable and difficult to predict. Most proposed risk factors are hypertension (HTN), diabetes mellitus (DM), and anticoagulant treatment. ...